According to new guidelines on venous thromboembolism (VTE) from ASH, pharmacologic prophylaxis is not recommended for patients experiencing major trauma deemed to be at high risk of bleeding.
David R. Anderson, MD, dean of the faculty of medicine at Dalhousie University stated that while pharmacologic prophylaxis reduce the risk of symptomatic pulmonary embolism and deep vein thrombosis by about 10 events per 1,000 patients, the increased risk of major bleeding (24 events per 1,000 patients) outweighs the benefits.
When pharmacologic prophylaxis is used, the panel recommends combined prophylaxis – mechanical prophylaxis in addition to pharmacologic prophylaxis – especially in those patients at high or very high risk of VTE. Evidence shows that the combination approach significantly reduces risk of PE, and strongly suggests it may also reduce risk of symptomatic proximal DVT.
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Source: https://www.mdedge.com/hematology-oncology/quiz/8776/fast-facts-friday/fast-facts-friday-december-13-2019?channel=59610
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